|
KMID : 0613820080180091202
|
|
Journal of Life Science
2008 Volume.18 No. 9 p.1202 ~ p.1206
|
|
|
Dendritic-like Cells Accumulate in BPD Lung of Baboon
|
|
Lee Jong-Hwan
Kim Kwang-Hyeon
|
|
|
Abstract
|
|
|
|
The present investigation demonstrates HLA-DR and PGP9.5 double positive cells accumulate thymus cortical region in normal baboon thymus and baboon lung. But, these cells disappeared in thymus and lung of bronchopulmonary dysplasia (BPD) animals. 125d GC animal model is more suitable for BPD than 140d GC animal. Anti-bombesin antibody, 2A11 treated baboon recover normal level of HLA-DR positive cells from BPD animal. In addition, thymocytes show responsiveness for bombesin. These observation suggest that blocking BLPs protects a chronic lung injury by BPD and 2A11 is possible agent for passive therapy of BPD.
|
|
|
KEYWORD
|
|
|
Bronchopulmonary dysplasia (BPD), 2A11, pro re nada (PRN), baboon, autoreactivity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|